高雪娇,中国共产党党员,博士,副教授,博士研究生导师,动物生理教研室主任。黑龙江省优秀青年基金获得者,东农学者学术骨干,中国畜牧兽医学会动物毒物学分会理事,国家自然基金函评专家,国家执业兽医是命题组专家,主要从事动物生理机能与疾病发生的调控机制研究,分析确定微量元素及相关蛋白在畜禽及水生动物等免疫功能调控过程中发挥的重要作用及相关机制,并结合北方寒区养殖特征深入基层,开展科技培训,指导动物疾病防控。先后主持国家自然基金、中国博士后基金、黑龙江省优秀青年基金、博士后科研启动基金、校企合作课题等项目,申请发明专利4项,先后在RedoxBiology、Science of the total environment、Food & function Microbiology spectrum发表SCI论文30余篇,其中中科院一区期刊论文10篇,入选ESI高被引论文6篇。讲授动物生理学、营养免疫学、动物生理学实验技术等本科及研究生课程,主持并参与各类教改课题多项,指导本科生获全国生命科学竞赛一等奖等奖项。
1.硒蛋白S介导内质网应激CHOP信号抑制乳腺金葡菌性炎症损伤调控机制,国家自然基金,主持
2.奶牛乳腺外泌体miRNA-146a对NLRP3炎性体调控机制,黑龙江省自然科学基金项目优秀青年项目,主持
3.中性粒细胞外捕网在氨气诱发鸡呼吸系统炎性损伤中的作用研究,博士后科研启动金项目,主持
4.动物硒蛋白调控机制,企业合作横向课题,主持
动物生理学、动物生理学实验、营养免疫学(研究生)、动物生理学实验技术(研究生)、定量药理学应用和机体系统的生理调节(研究生)
1.Wu, Jiawei; Zhang, Yanhe; Liu, Tianjing; Yang, Jie; Sun, Xiaoran;Gao, Xue-jiao.The mechanism of selenium regulating the permeability of vascular endothelial cells through selenoprotein O. REDOX BIOLOGY. 2024, 70: 103063.中科院一区,IF=10.7.
2.Yang, Jie; Geng, Yuan; Zhao, Bing; Liu, Tianjing; Luo, Ji-long; Gao, Xue-jiao. Green tea polyphenols alleviate TBBPA-induced gastric inflammation and apoptosis by modulating the ROS-PERK/IRE-1/ATF6 pathway in mouse models. FOOD & FUNCTION. 2024, 15(19): 10179-10189.中科院一区,IF=5.1.
3.Sun, Xiaoran; Xu, Shuang; Liu, Tianjing; Wu, Jiawei; Yang, Jie; Gao, Xue-jiao. Zinc supplementation alleviates oxidative stress to inhibit chronic gastritis via the ROS/NF-κB pathway in a mouse model. FOOD & FUNCTION. 2024, 15(13): 7136-7147.中科院一区,IF=5.1.
4.Lv, Hongli; Wang, Jingjing; Geng, Yuan; Xu, Tianchao; Han, Fuxin; Gao, Xue-jiao; Guo, Meng-yao Green tea polyphenols inhibit TBBPA-induced lung injury via enhancing antioxidant capacity and modulating the NF-κB pathway in mice. FOOD & FUNCTION. 2024, 15(7): 3411-3419.中科院一区,IF=5.1.
5.Li, Xueying; Xu, Shuang; Zhang, Yanhe; Li, Kan; Gao, Xue-Jiao; Guo, Meng-yao. Berberine Depresses Inflammation and Adjusts Smooth Muscle to Ameliorate Ulcerative Colitis of Cats by Regulating Gut Microbiota. MICROBIOLOGY SPECTRUM. 2022, 10(6): 03207-22.中科院一区,IF=9.9.
6.Jing, Hongyuan; Zhang, Qirui; Gao, Xue-Jiao. Excessive lithium of water induced a toxic effect on kidney via oxidative damage and inflammation in carp. AQUACULTURE. 2021, 535: 736282.中科院一区,IF=5.1.
7.Jing, Hongyuan; Wang, Shengchen; Wang, Yue; Shen, Naiwen; Gao, Xue-jiao. Environmental contaminant ammonia triggers epithelial-to-mesenchymal transition-mediated jejunal fibrosis with the disassembly of epithelial cell-cell contacts in chicken.SCIENCE OF THE TOTAL ENVIRONMENT.2020, 726: 138686.中科院一区,IF=10.7.
8.Liu, Tian-jing; Yang, Jie; Wu, Jia-wei; Sun, Xiao-ran; Gao, Xue-jiao Polyethylene microplastics induced inflammation via the miR-21/IRAK4/ NF-κB axis resulting to endoplasmic reticulum stress and apoptosis in muscle of carp. FISH & SHELLFISH IMMUNOLOGY. 2024, 145: 109375.