李继昌,女,1966年3月生,东北农业大学动物医学学院教授,博士生导师,基础兽医学学科带头人,东农学者计划高层次人才学术英才。1989年获东北农业大学农学学士学位;1992年获东北农业大学兽医药理学与毒理学硕士学位;2002年获东北农业大学兽医病理学博士。1992-1996年于黑龙江省医药工业研究所药理研究室从事药理学科研工作(主管药师);1996-至今于东北农业大学动物医学学院药理教研室从事兽医药理学与毒理学教学与科研工作(教授,博士生导师);2002-2005年于黑龙江省中医研究院中药研究所博士后工作站,从事中药新药研发(博士后);2008-2009年于澳大利亚蒙纳什大学药学院FADDI研究室,从事抗微生物药物多黏菌素B的药代动力学研究(访问学者)。
主要研究方向为新兽药研发与应用、兽医药理学与毒理学安全评价、动物疫病防控等。主持国家自然科学基金、黑龙江省自然科学基金及其黑龙江省高校科技成果产业化前期研发培育项目等科研课题30余项。发表科技论文200余篇,其中SCI收录70余篇;授权国家及国际发明专利7项,出版教材著作10余部;获黑龙江省高教科学研究优秀成果三等奖1项,黑龙江省科技发明一等奖2项,黑龙江科技进步二等奖2项,黑龙江科技进步三等奖2项;获东北农业大学第二届振兴东农教学质量优秀三等奖、第四届“成栋杯”教职工综合素质大赛教学技能二等奖、第七届教职工综合素质大赛教学技能一等奖;主讲的《兽医药理学》获黑龙江省精品课程。
人才称号:东农学者计划高层次人才学术英才称号
农业农村部兽药评审咨询专家库专家;第七届中国兽药典委员会委员;中国毒理学会兽医毒理专业委员会常务委员兼副秘书长;全国执业兽医资格考试命题专家;国家科技专家库专家;中国兽药协会宠物医药分会智库专家;中国畜牧兽医学会兽医毒物学学会理事;黑龙江省生理学会常务理事;黑龙江省畜牧兽医学会常务理事及动物药物学分会秘书长;《中国农业科学》、《黑龙江畜牧兽医》等杂志编委。
1.NGF及其PI3-K/Akt信号通路在黏菌素致周围神经毒性中的作用及机制研究,国家自然基金,项目批准号:31272613,直接费用:80万元,项目起止年月:2013-2016
2.黏菌素诱导神经细胞线粒体自噬与凋亡的交叉对话及p53双重调控机制研究, 国家自然基金,项目批准号:31472240,直接费用:83万元,项目起止年月:2015-2018
3.黄芩苷通过调控细胞自噬和TLR2信号通路干预鸡毒支原体感染炎症反应的机制研究,国家自然基金,项目批准号:31772801,直接费用:62万元,项目起止年月:2018-2021
4.肠道菌群与鸡毒支原体感染肺部炎症反应的“肠-肺轴”互作机制及靶向干预研究,项目批准号:31973005,直接费用: 59万元,项目起止年月:2020.01-2023.12
5.黄芩苷调控鸡毒支原体胞外囊泡与宿主相互作用抑制巨噬细胞铁死亡的机制研究,国家自然基金,项目批准号:32273062,直接费用:54万元,项目起止年月:2023-2026
6.猫眼草酚D靶向干预鸡毒支原体胞外囊泡TatD核酸酶抑制中性粒细胞胞外诱捕网降解的机制研究,国家自然基金,项目批准号:32473096,直接费用:50万元,项目起止年月:2025-2028
1.兽医药理学,80学时,本科生必修课
2.兽药与食品安全,48学时,学术型硕士选修课
3.生物信息学分析与实践,32学时,学术型博士选修课
4.基础兽医学科前沿讲座与研讨,8/48学时,学术型博士核心课
5.基础兽医学科前沿专题讲座,8/32学时,专业型硕士核心课
1.Lige Bao, Yongze Huang,Fuhua Gu,Weiqi Liu,Yuquan Guo,Hao Chen, Kung Wang,Zhiyong Wu*,Jichang Li*.Zearalenone induces liver injury in mice through ferroptosis pathway. Science of the Total Environment, 2024, 952, 175875 (中科院1区,TOP)
2.Shun Wang, Liyang Guo, Fuhua Gu, Jiaxin Bao,Yuquan Guo, Yongjie Zhang, Rui Li, Zhiyong Wu*, Jichang Li*.Quercetin helps to restore the imbalanced respiratory mucosal barrier in MG-infected chicks by enhancing Th2 immune response. PHYTOMEDICINE,2024,133,155953 (中科院1区,TOP)
3.Kexin Wang,Yusong Miao,Weiqi Liu, Muhammad Ishfaq,Jiaxin Bao, Xiaodi Jin, Zhiyong Wu,Rui Li,Chunli Chen, Jichang Li*Lactobacillus salivariusamelioratedMycoplasma gallisepticum-induced inflammation via JAK/STAT signaling pathway involving respiratory microbiota and metabolites. Poultry Science,2024, 103:103942(中科院1区,TOP)
4.Yuquan Guo, Yusong Miao,Hao Chen, Kexin Wang, Shun Wang, RuiWang, Zhiyong Wu, Jichang Li*.Revealing the Mechanism: The Influence of Baicalin on M1/M2 and Th1/Th2 Imbalances inMycoplasma gallisepticumInfection.Poultry Science,2024, 103:104145(中科院1区,TOP)
5.Yusong Miao, Dong Niu, Ze Wang, Jian Wang, Zhiyong Wu, Jiaxin Bao, Xiaodi Jin, Rui Li, Muhammad Ishfaq, and Jichang Li*.Methylsulfonylmethane ameliorates inflammation via NF-kappaB and ERK/JNK-MAPK signaling pathway in chicken trachea and HD11 cells duringMycoplasma gallisepticuminfection. Poultry Science, 2022,101:101706(中科院1区,TOP)
6.Jian Wang, Muhammad Ishfaq*and Jichang Li*.Baicalin amelioratesMycoplasma gallisepticuminduced inflammatory injury in the chicken lungthrough regulating the intestinal microbiota andphenylalanine metabolism. Food & Function, 2021, 12:4092-4104(中科院1区,TOP)
7.Jiaxin Bao, Zhiyong Wu, Muhammad Ishfaq, Jian Wang, Yusong Miao, Dong Niu, Rui Li, Jichang Li*, Chunli Chen*.Pharmacokinetic/pharmacodynamicprofiles ofbaicalin againstMycoplasma gallisepticumin aninvivoinfectionmodel. Poultry Science, 2021,100:101437(中科院1区,TOP)
8.Zhiyong Wu,Chunli Chen, Qiaomei Zhang, Jiaxin Bao,QianqianFan,RuiLi, Ishfaq Muhammad*, Jichang Li*. Arachidonic Acid MetabolismisElevated inMycoplasma gallisepticumand Escherichia coli Co-infection and Induces LTC4 in Serum as the Biomarker for Detecting Poultry Respiratory Disease. Virulence,11(1): 730-738(中科院1区,TOP)
9.Ishfaq Muhammad, Wanying Hu,Mohammad Zeb Khan,Ijaz Ahmad,Wenxin Guo*,Jichang Li*.Current status of vaccine research, development and challenges of vaccines forMycoplasma gallisepticum. Poultry Science, 2020, 99(9):4195-4202(中科院1区,TOP)
10.Zhiyong Wu, Qianqian Fan, Yusong Miao, Erjie Tian,y Muhammad Ishfaq*, Jichang Li*. Baicalin inhibits inflammation caused by coinfection ofMycoplasma gallisepticumandEscherichia coliinvolving IL-17 signaling pathway. Poultry Science, 2020, 99:5472-5480(中科院1区,TOP)
11.Jichang Li,Zujian Qiao, Wanying Hu, Wei Zhang, Syed Waqas Ali Shah, Muhammad Ishfaq*.Baicalin mitigatedMycoplasma gallisepticum-induced structural damage and attenuated oxidative stress and apoptosis in chicken thymusthrough theNrf2/HO-1 defense pathway. Veterinary research, 2019, 50:83(中科院1区,TOP)
12.Ishfaq Muhammad#, Chunli Chen#, Jiaxin Bao, Wei Zhang, Zhiyong Wu, Jian Wang, Yuhao Liu, Erjie Tian,Sattar Hamid, Rui Li, Liangjun Ding*, Jichang Li*.Baicalin ameliorates oxidative stress and apoptosis by restoring mitochondrial dynamics in the spleen of chickens via the opposite modulation of NF-kB and Nrf2/HO-1 signaling pathway duringMycoplasma gallisepticuminfection.Poultry Science, 2019,98:6296–6310(中科院1区,TOP, ESI)
13.Chen Chunli#, Jichang Li#, Wei Zhang,Syed Waqas Ali Shah, Muhammad Ishfaq*.Mycoplasma gallisepticumtriggers immune damage in the Chicken Thymus by activating the TLR-2/MyD88/NF-κB signaling pathway and NLRP3 inflammasome. Veterinary research,2020, 51:52(中科院1区,TOP, ESI)
14.主编,兽医药理学,国家林业和草原局普通高等教育“十三五”规划教材,中国林业出版社,2021.
15.副主编,兽医药剂学(第三版),普通高等教育农业农村部“十四五”规划教材,中国农业出版社,2024
本团队主要研究方向为药物通过调控鸡毒支原体胞外囊泡与宿主相互作用抑制免疫细胞死亡的作用机制。目前在研博士研究生7人,硕士研究生14人,其中留学生2人。