1.国家十四五重点研发计划专项“动物重要病原耐药性控制机制”子项目“NDM-1和/或NDM-5抑制剂活性化合物构效关系及其作用机制研究”,主持,70万2023.12-2026.12, 批准号:2023YFD1800102
2.Vidofludimus协同β-内酰胺类抗生素抗NDM-1阳性E.coli的作用机制研究,国自然面上项目,主持,52万,2023.01-2026.12,批准号:32273060
3.基于LncRNA769044-ceRNA-miR1679对靶点STAT1的调控探讨姜黄素干预鸡AFB1性肝细胞程序性坏死的分子机制,国家自然基金面上项目,32072918,58万,2021-2024
4.国家十三五重点研发计划专项:“畜禽重要耐药病原菌耐药耐药性检测与控制技术”子项目“畜禽病原菌耐药性检测标准研究”,主持,59万,201601-202012,59,批准号:2016YFD0501302
5.国家十三五重点研发计划专项:“畜禽药物的代谢转归和耐药性形成机制研究”子项目“畜禽重要病原菌关键耐药蛋白机制确证和抑制剂筛选”主持,38万,20180601-20201231批准号:2018YFD0500306,
6.黑龙江省自然基金重点项目:Nrf2信号通路对NAFLD小鼠药物代谢酶基因表达的调控
主持,20万,2014-2016,ZD201405
7.非酒精性脂肪肝增量表达CYP2A5的作用机制及其发病机制, 国家自然基金面上项目,主持,62万元,2009-2013,项目批准号:31172369
8.中加科技合作项目:Collaborative Research Partnership on Emerging Pathogens Affecting Food Safety andSecurity,参加,2009-2010,加拿大圭尔夫大学
9.科技部科技人员服务于企业项目,年产48万支兽用乳塞通注射液,主持, 2009-2011,项目编号2006GJB20009。
10.国家自然基金合作交流项目《非酒精性脂肪肝及药物对CYP2A5调节机理研究》,2010.1-2010.12,2.9万元,项目编号30871891 30910416
11.“十一五”国家科技支撑计划课题《兽用复方新制剂的研制与应用》子课题 “抗猪链球菌病复方制剂的药动学研究》,主持,2007.12-2010.12,课题编号:2006BAD31B08
12.黑龙江省对外合作项目《分子修饰提高中药多糖抗病毒活性已发现新型先导化合物研究》,主持人,WB08B01,10万元
13.国家自然基金项目《脂肪肝及药物对CYP2A5代谢影响及作用机制研究》2009-2011, 主持,33万元,编号:30871891,
14.农业部残留质量标准制订《动物性食品中安普霉素残留检测方法研究—HPLC法》,主持,8万元,2007-2008。
15.20.黑龙江省重点攻关项目, 防治奶牛乳腺炎新型药物的研制与开发,主持,10万元,2006-2009年,项目编号GA06B202-3
16.国家科技重大科技专项“松花江水硝基苯污染对农业生产的危害及其产品安全性影响研究”子项目“松花江水硝基苯污染对畜牧业生产的危害及其产品安全性影响研究”,主持. 35万元, 2005.12-2006.7 项目编号2006BA618A
17.黑龙江省科技厅项目:松花江水硝基苯污染对畜牧业生产的危害及其产品安全性影响研究》,2005-2006,主持人,10万元GB06C215-05
18.黑龙江江省博士后科研启动金项目《安普霉素耐药性及其消除研究》2004-2006年,编号:LHK-04024,五万元
19.黑龙江省自然基金,安普霉素耐药大肠杆菌耐药基因研究,主持,5万元,2002-2005项目编号C0313
20.黑龙江省科委“十五”攻关项目,北方中兽药的开发与研制,主持,10万元2001.5-2004.5
1.抗鸡新城疫病毒中药复方制剂的研制与应用,2009,获黑龙江省科技进步二等奖,第一名。
2.抗鸡新城疫病毒中药复方制剂的研制与应用,2009,获黑龙江省畜牧局科技进步一等奖,第一名。
3.中草药添加剂及其防治疾病作用研究,2002,获黑龙江省科技进步三等奖,第一完成人,
4.奶牛重要疫病防治技术研究与产业化开发,2011年,获黑龙江省畜牧局科技进步一等奖,第2名
授权专利:
1.治疗奶牛乳腺炎中药透皮软膏及其制备方法,发明专利,授权号:ZL200810136934.2,授权日:2011.06,第一发明人
2.同时检测小鼠血液和肝脏组织中脂肪酸含量的气相色谱方法,第一发明人,专利号:ZL201510312760.0,授权日:20160831
3.同时检测肉鸡肝脏、肾脏和鸡肉中黄曲霉毒素B1和M1含量的超高效液相色谱方法,ZL201710029292.5,2020.01,第一发明人
4.地拉考昔的制备方法,发明专利,授权专利号:ZL201710782111.6,授权专利日:2020.03,第一发明人。
5.氨磷汀作为NDM-1抑制剂或抗生素保护剂的新用途,发明专利,授权专利号:ZL202111065290,第一发明人;授权日期:202308。
6.倍他洛尔作为NDM-1抑制剂或抗生素保护剂的新用途,发明专利,授权专利7:ZL 2021 1 1065289.1,第一发明人;2024.04。
8.维多氟拉迪莫作为NDM-1抑制剂或抗生素保护剂的新用途,发明专利,授权专利号:ZL 2021 1 1065294.2,第一发明人;2024.03年。
9.酞磺醋胺作为NDM-1抑制剂或抗生素保护剂的新用途,发明专利,授权专利号:ZL 2021 1 1065293.8,第一发明人;2024.07。
兽药证书:
1.中华人民共和国农业农村部:加米霉素注射液,二类新兽药,2020.05
1.《兽医药物分析》,面向21世纪统编教材,中国农业出版社,主编:张秀英,2008.8 ISBN978-7-109-12112-6
3.《兽医药物分析》,面向21世纪普通农业高等院校规划教材,中国农业出版社 ,主编,2018.04,ISBN978-7-109-23766-3
4.《兽医药理学与治疗学》操继跃 刘雅虹主译,张秀英副主译, 十二五国家重点图书出版规划项目,世界兽医经典著作译丛 ,中国农业出版社,ISBN978-7-109-16066-8 2012.6
5.SihongLi,*,y,1YixinZhang,*,1MuhammadIshfaq,zRuimengLiu,*GaoqiangWei,*andXiuyingZhang*,2CurcuminalleviatesAflatoxinB1-triggeredchickenlivernecroptosisbytargetingtheLOC769044/miR-1679/STAT1axis。2024 Poultry Science 103:103883,中科院一区,3.8,top。
6.Xiaoting Lia,b, Dongmei Zhaoa, Xinrong Zhaoa, Ping Chenga, Fulei Lia, Jichao Suna, Yubao Lib, Jingwen Baia,c,**, Xiuying Zhanga,*。The activity and mechanism of vidofludimus as a potent enzyme inhibitor against NDM-1-positive E. coli. European Journal of Medicinal Chemistry 250 (2023) 115225,中科院一区,7.088,top
7.Yixin Zhanga, Yikang Wanga, Yaozu Yanga, Dongmei Zhaoa, Ruimeng Liua, Sihong Lic,*,Xiuying Zhangb,*Proteomic analysis of ITPR2 as a new therapeutic target for curcumin protection against AFB1-induced pyroptosis,Ecotoxicology and Environmental Safety,260 (2023) 115073,中科院二区,7.129, top
8. Ruimeng Liua, Yixin Dingb, Weina Lia, Sihong Lic, Xiaoting Lid, Dongmei Zhaoa, Yixin Zhanga, Gaoqiang Weia, Xiuying Zhanga,*。Protective role of curcumin on broiler liver by modulating aflatoxin B1-induced DNA methylation and CYPs expression。Ecotoxicology and Environmental Safety 260 (2023) 115086,中科院二区,7.129, top
9.Jichao Sun 1,2, Shangjie Ren 1,2, Yaozu Yang 1,2, Xiaoting Li 1,2 and Xiuying Zhang 1,2,*Betaxolol as a Potent Inhibitor of NDM-1-Positive E. coli That Synergistically Enhances the Anti-Inflammatory Effect in Combination with Meropenem,Int. J. Mol. Sci. 2023, 24, 13399
10. Sihong Lia,b, Ruimeng Liua, Shun Xiaa, Gaoqiang Weia, Muhammad Ishfaqa,c, Yixin Zhanga,Xiuying Zhanga, Protective role of curcumin on aflatoxin B1-induced TLR4/RIPK pathway mediated-necroptosis and inflammation in chicken liver,Ecotoxicology and Environmental Safety,2022,233:113319,二区,7.129,top
11. Xiaoting Li1,2, Dongmei Zhao1,2, Weina Li1,2, Jichao Sun1,2and Xiuying Zhang1,2,*Enzyme Inhibitors: The Best Strategy to Tackle Superbug NDM-1 and Its Variants, Int. J. Mol. Sci. 2022, 23, 197 二区, top 6.208
12. Fulei Li1,2, Ping Cheng1,2, Xiaoting Li1,2, Ruimeng Liu1,2, Haibin Liu1,2and
Xiuying Zhang1,2*Molecular Epidemiology and Colistin-Resistant Mechanism of mcr-Positive and mcr-Negative Escherichia coli Isolated From Animal in Sichuan Province, China。Frontiers in Microbiology,March 2022 | Volume 13 | Article 818548。二区,top 6.064
13. Sihong Li1,2, Meiyu Han1, Yixin Zhang1, Muhammad Ishfaq1, Ruimeng Liu1, Gaoqiang Wei1, Xiuying Zhang3,*and Xiuying Zhang1,*Effect of Curcumin as Feed Supplement on Immune Response and Pathological Changes of Broilers Exposed to Aflatoxin B1。Biomolecules,2022, 12, 1188,二区,6.061
14. Ping Cheng1, Yuqi Yang2, Sai Cao1, Haibin Liu1, Xiaoting Li1, Jichao Sun1, Fulei Li1,Muhammad Ishfaq1and Xiuying Zhang1*. Prevalence and Characteristic of Swine-Origin mcr-1-Positive Escherichia coli in Northeastern China. Frontiers in Microbiology, 2021,12: 712707.中科院二区. 6.02, top
15.Li S, Liu R, Wei G, Guo G, Yu H, Zhang Y, Ishfaq M, Fazilani SA, Zhang X. Curcumin protects against Aflatoxin B1-induced liver injury in broilers via the modulation of long non-coding RNA expression. Ecotoxicol Environ Saf. 2021 Jan 15;208:111725.二区,top,7.129
16.Cheng P, Ishfaq M, Yu H, Yang Y, Li S, Li X, Fazlani SA, Guo W, Zhang X. Curcumin ameliorates duodenal toxicity of AFB1 in chicken through inducing P-glycoprotein and downregulating cytochrome P450 enzymes. Poult Sci. 2020 Dec;99(12):7035-7045.中科院一区,4.014;
17.Li S, Muhammad I, Yu H, Sun X, Zhang X. Detection of Aflatoxin adducts as potential markers and the role of curcumin in alleviating AFB1-induced liver damage in chickens. Ecotoxicol Environ Saf. 2019;176:137–145. doi:10.1016/j.ecoenv. 2019.03.089 二区7.129
18.Muhammad I, Wang H, Sun X, et al. Dual Role of Dietary Curcumin Through Attenuating AFB1-Induced Oxidative Stress and Liver Injury via Modulating Liver Phase-I and Phase-II Enzymes Involved in AFB1 Bioactivation and Detoxification. Front Pharmacol. 2018;9:554. Published 2018 May 25. doi:10.3389/fphar.2018.00554 二区 5.988
19.Xinghe, Wang, Wei Li, Xinghui Wang, Meiyu Han, Ishfaq Muhammad, Xiuying Zhang*, Xiaoqi Sun, Xiaoxu Cui. Water-soluble substances of wheat: a potential preventer of aflatoxin B1-induced liver damage in broilers. Poult Sci, 2019. 98(1): 136-149. 二区4.014
20Ishfaq, Muhammad, Xiaoqi Sun, He Wang, Wei Li, Xinghe Wang, Ping Cheng, Sihong Li, Xiuying Zhang*, Hamid Khan. Curcumin Successfully Inhibited the Computationally Identified CYP2A6 Enzyme-Mediated Bioactivation of Aflatoxin B1 in Arbor Acres broiler. Front Pharmacol, 2017. 8: 143. 二区,5.988
21.Xiaoxu, Cui, Ishfaq Muhammad, Rui Li, Huiran Jin, Zhaolin Guo, Yuqi Yang, Sattar Hamid, Jiarui Li, Ping Cheng, Xiuying Zhang*. Development of a UPLC-FLD Method for Detection of Aflatoxin B1 and M1 in Animal Tissue to Study the Effect of Curcumin on Mycotoxin Clearance Rates. Front Pharmacol, 2017. 8: 650. 二区,5.988
22.Xinghe Wang, Xiaoxu Cui, Xiaoqi Sun, Xinghui Wang, Xiaochong Li, Yue Qi, Wei Li, Meiyu Han, Ishfaq Muhammad, Xiuying Zhang*. High Fat Diet-Induced Hepatic 18-Carbon Fatty Acids Accumulation Up-Regulates CYP2A5/CYP2A6 via NF-E2-Related Factor 2. Frontiers in Pharmacology, 2017. 8: 233. 二区,5.988
23.Xu, G., W. An, H. Wang, X. Zhang. Prevalence and characteristics of extended-spectrum β-lactamase genes in Escherichia coli isolated from piglets with post-weaning diarrhea in Heilongjiang province, China. Frontiers in Microbiology, 2015. 6: 1103.二区,5.988
24.Yizhe, Cui, Qiuju Wang, Xiaochong Li, Xiuying Zhang*. Experimental nonalcoholic fatty liver disease in mice leads to cytochrome p450 2a5 upregulation through nuclear factor erythroid 2-like 2 translocation. Redox Biology, 2013. 1(1): 433-440.一区,10.787
25.Chunhua, Wang, Yizhe Cui, Chunyan Li, Yanhua Zhang, Shang Xu, Xiaochong Li, Hong Li, Xiuying Zhang*. Nrf2 deletion causes “benign” simple steatosis to develop into nonalcoholic steatohepatitis in mice fed a high-fat diet. Lipids in Health & Disease, 2013. 12(1): 165-165.二区,3.9
26.Xin Wang, Yuzhen Cao, Yunwei Fu, Guifang Guo, Xiuying Zhang*. Liver fatty acid composition in mice with or without nonalcoholic fatty liver disease. Lipids in Health & Disease, 2011. 10(1): 234-234.二区,3.9