兽医微生物学与免疫学教研室

姓名: 葛俊伟

职称: 教授

系别: 预防兽医学系

研究领域: 肠道健康与免疫调控

办公电话: 0452-55190385

电子邮箱: gejunwei@neau.edu.cn

个人简介
人才称号
科研项目
讲授课程
论文著作

葛俊伟,1977年生,博士,博士生导师,教授,东农学者学术骨干,美国佛罗里达大学访问学者,长期从事动物肠道健康与免疫调控基础与应用相关研究,在FASEB J和Int J Biol Macromol等刊物发表文章80余篇,先后主持国家、省部级项目10项,获得国家发明专利6项,获黑龙江省科技发明二等奖等2项,副主编或参编专著与教材6部,曾获东北农业大学课堂教学改革优秀案例一等奖、课堂教学质量奖三等奖各1项,全国大学生动物医学专业技能大赛特等奖等奖项指导教师。

东农学者学术骨干

1.乳酸菌调控Nrf2信号通路对断奶仔猪腹泻肠黏膜屏障损伤的保护作用与机制(31672532),国家自然科学基金项目,2017.1-2020.12

2.功能性复合中药饲料专用菌种解析与升级,横向课题,2022.1-2024.12

3.水貂阿留申生物安全防控技术体系建设,横向课题,2023.11-2024.11

传染病综合诊治大实验、生物制品学与免疫学

1.Guo Z, Ren H, Chang Q, Liu R, Zhou X, Xue K, Sun T, Luo J, Wang F, Ge J. Lactobacilli-derived adjuvants combined with immunoinformatics-driven multi-epitope antigens based approach protects against Clostridium perfringens in a mouse model. Int J Biol Macromol. 2024 May;267(Pt 2):131475. doi: 10.1016/j.ijbiomac.2024.131475.

2.Jia Z, Liu R, Chang Q, Zhou X, De X, Yang Z, Li Y, Zhang C, Wang F, Ge J. Proof of concept in utilizing the peptidoglycan skeleton of pathogenic bacteria as antigen delivery platform for enhanced immune response.Int J Biol Macromol. 2024 Apr;264(Pt 1):130591. doi: 10.1016/j.ijbiomac.2024.130591.

3.Zhang Z, De X, Sun W, Liu R, Li Y, Yang Z, Liu N, Wu J, Miao Y, Wang J, Wang F, Ge J. Biogenic Selenium Nanoparticles Synthesized by L. brevis 23017 Enhance Aluminum Adjuvanticity and Make Up for its Disadvantage in Mice. Biol Trace Elem Res. 2024 Oct;202(10):4640-4653. doi: 10.1007/s12011-023-04042-y. Epub 2024 Jan 26.

4.Li H, Niu L, Wang J, Chang Q, Zhang S, Wang J, Zeng J, Gao M, Ge J. Strategy against super-resistant bacteria: Curdlan-induced trained immunity combined with multi-epitope subunit vaccine. Int J Biol Macromol. 2024 Sep 14;280(Pt 1):135663. doi: 10.1016/j.ijbiomac.2024.135663.

5.Niu L, Gao M, Ren H, De X, Jiang Z, Zhou X, Liu R, Li H, Duan H, Zhang C, Wang F, Ge J. A novel bacterium-like particles platform displaying antigens by new anchoring proteins induces efficacious immune responses. Front Microbiol. 2024 May 22;15:1395837. doi: 10.3389/fmicb.2024.1395837. eCollection 2024.

6.Niu L, Gao M, Wen S, Wang F, Shangguan H, Guo Z, Zhang R, Ge J. Effects of Catecholamine Stress Hormones Norepinephrine and Epinephrine on Growth, Antimicrobial Susceptibility, Biofilm Formation, and Gene Expressions of Enterotoxigenic Escherichia coli. Int J Mol Sci. 2023 Oct 27;24(21):15646. doi: 10.3390/ijms242115646.

7.Runhang Liu, Weijiao Sun, Tianzhi Sun, Wenzhi Zhang, Yongchao Nan, Zheng Zhang, Kongrui Xiang, Hongliang Yang, Fang Wang, Junwei Ge. Nano selenium-enriched probiotic Lactobacillus enhances alum adjuvanticity and promotes antigen-specific systemic and mucosal immunity. Front. Immunol., 27 January 2023, 1116223 https://doi.org/10.3389/fimmu.2023.1116223

8.Zhou X, Gao M, De X, Sun T, Bai Z, Luo J, Wang F, Ge J. Bacterium-like particles derived from probiotics: progress, challenges and prospects. Front Immunol. 2023 Oct 6;14:1263586. doi: 10.3389/fimmu.2023.1263586. eCollection 2023.

9.Xin W, Guo Z, Wang L, Li Y, Shangguan H, Xue K, Chen H, Yang H, Zhao L, Ge J. Multiple genotypes infection and molecular characterization of Torque teno neovison virus: A novel Anelloviridae of mink in China. Res Vet Sci. 2023 Aug;161:145-155. doi: 10.1016/j.rvsc.2023.06.021. Epub 2023 Jun 25.

10.Chen H, Sun X, He H, Ren H, Duan H, Zhang C, Chang Q, Zhang R, Ge J. Lysinibacillus capsici 38,328 isolated from agricultural soils as a promising probiotic candidate for intestinal health. Arch Microbiol. 2023 May 30;205(6):251. doi: 10.1007/s00203-023-03593-x.

11.Li N, Bai Y, Liu R, Guo Z, Yan X, Xiang K, Liu F, Zhao L, Ge J. Prevalence and genetic diversity of canine coronavirus in northeastern China during 2019-2021. Comp Immunol Microbiol Infect Dis. 2023 Mar;94:101956. doi: 10.1016/j.cimid.2023.101956.

12.Xiang K, Zhang Z, Li N, Zhang P, Liu F, Li H, Duan H, Zhang C, Ge J. Whole-Genome Sequence and Pathogenicity Analysis of Providencia Heimbachae Causing Diarrhea in Weaned Piglets. Curr Microbiol. 2023 Oct 9;80(11):364. doi: 10.1007/s00284-023-03478-8.

13.W Sun, H Liu, J Liu, Q Jiang, Y Pan, Y Yang, X Zhu, J Ge. Detection of optrA and poxtA genes in linezolid-resistant Enterococcus isolates from fur animals in China. Lett Appl Microbiol. 2022 Dec;75(6):1590-1595. doi: 10.1111/lam.13826. Epub 2022 Sep 13.

14.Ziqi Shi, Naiyu Guan, Weijiao Sun, Tianzhi Sun, Lingdi Niu, Jinyu Li, Junwei Ge. Protective Effect of Levilactobacillus brevis Against Yersinia enterocolitica Infection in Mouse Model via Regulating MAPK and NF-κB Pathway. Probiotics Antimicrob Proteins. 2022 Oct;14(5):830-844. doi: 10.1007/s12602-022-09957-x. Epub 2022 Jun 4. PMID: 35665480 DOI: 10.1007/s12602-022-09957-x

15.Zhuo Zhang, Lili Zhao, Manman Song, Jilong Luo, Hanghang Liu, Kun Xue, Chengshi Huang, Hongyan Chen, Junwei Ge. Providencia heimbachae Associated with Post-weaning Diarrhea in Piglets: Identification, Phenotype, and Pathogenesis. Curr Microbiol. 2021 Dec 4;79(1):1. doi: 10.1007/s00284-021-02697-1.

16.Guo Z, Wang L, Niu L, Shangguan H, Huang C, Yi Y, Zhang Y, Gao M, Ge J.Genetic and evolutionary analysis of emerging HoBi-like pestivirus. Res Vet Sci, 137 (2021) 217–225

17.Lin Wang, Yifan Li, Zhiyuan Guo, Ying Yi, Han Zhang, Haikun Shangguan, Chengshi Huang, Junwei Ge. Genetic changes and evolutionary analysis of canine circovirus. 2.574 Arch Virol. 2021 Aug;166(8):2235-2247. doi: 10.1007/s00705-021-05125-8.

18.Xin W, Liu Y, Yang Y, Sun T, Niu L, Ge J. Detection, genetic, and codon usage bias analyses of the VP2 gene of mink bocavirus. Virus Genes. 2020 Jun;56(3):306-315. doi: 10.1007/s11262-020-01738-4.

19.Wang Z, Shi Y, Wang Y, Zhao L, Cui X, Wen S, Liu H, Cui W, Chen H, Ge J. Detection of Antibodies Against Canine Circovirus in Naturally and Experimentally Infected Canines by Recombinant Capsid Enzyme-Linked Immunosorbent Assay. Front Vet Sci. 2020 May 28;7:294. doi: 10.3389/fvets.2020.00294. eCollection 2020.

20.Lingdi Niu, Zheng Wang, Lili Zhao, Yu Wang, Xingyang Cui, Yunjia Shi, Hongyan Chen, Junwei Ge. Detection and molecular characterization of canine circovirus circulating in northeastern China during 2014-2016. Arch Virol. 2020 Jan;165(1):137-143. doi: 10.1007/s00705-019-04433-4.