兽医内科学教研室

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姓名: 林洪金

职称: 教授

系别: 四级

研究领域: 临床兽医学

办公电话:

电子邮箱: linhongjin@neau.edu.cn

个人简介
人才称号
社会兼职
科研项目
讲授课程
论文著作
制定地方标准

林洪金,男,生于1970年2月,中共党员,博士,教授,博士研究生导师。2003年于东北农业大学临床兽医专业研究生毕业,博士学位,研究方向为动物营养代谢病与中毒病,主要从事兽医临床诊断等相关的教学工作。

主持省青年基金1项,省自然联合基金1项,市攻关课题1项,动物营养学国家重点实验室开放课题1项,国家生猪产业技术体系子课题1项,横向课题1项,省教改工程课题1项,校思政课教改项目2项。以第一作者和通讯作者发表发表论文60余篇,其中SCI论文40余篇。主编出版教材2部。获得发明专利4项,获国家教学成果二等奖1项。任教育部高等学校高职高专动物生产专业类教学指导委员会副主任委员(2006-2010)。

获东北农业大学2022年度“东农学者计划”学术英才YC1称号

教育部高等学校高职高专动物生产专业类教学指导委员会,副主任委员(2006-2010)

中国畜牧兽医学会兽医内科与临床诊疗学分会 动物毒物学分会理事(2018至今)

黑龙江省畜牧兽医学会兽医内科学分会常务理事(2019-2022)


(1)主持 横向项目 中兽药替代抗生素的研究与应用2022.01-2025.12经费100万。

(2)主持 黑龙江省科学技术厅联合项目 硒蛋白K诱导鸡缺硒性肝细胞凋亡作用的研究(LH2020C025) 2020.07-2023.07 10万。

(3)主持 中华人民共和国科学技术部国家生猪产业技术体系重大项目-子课题 仔猪腹泻类疾病的智能化监测与预警(CARS-35) 2018.08-2020.08 6万。

(4)主持 动物营养学国家重点实验室开放课题 能量代谢在环境硫化氢致鸡中性粒细胞外捕网形成障碍作用机制的研究(2004DA125184F1716) 2017.10-2018.10 15万。

(5)主持 黑龙江省科学技术厅青年基金项目 奶牛低酸度酒精阳性乳症产生的分子机理的研究(QC03C37) 2003.01-2005.12 10万。


(1)兽医临床诊断学(本科)

(2)兽医影像学(本科)

(3)高级兽医临床诊断专题(硕士生)

(4)兽医内科现代临床诊疗技术(博士生)


论文:

1.Cui Y, Yin K, Zheng Y, Wang B, Qu Y, Li S, Lin H. Mixed plasticizers aggravated apoptosis by NOD2-RIP2-NF-κB pathway in grass carp hepatocytes. J Hazard Mater. 2021 Jan 15;402:123527. doi: 10.1016/j.jhazmat.2020.123527.

2.Cui Y, Zhang X, Yin K, Qi X, Zhang Y, Zhang J, Li S, Lin H. Dibutyl phthalate-induced oxidative stress, inflammation and apoptosis in grass carp hepatocytes and the therapeutic use of taxifolin. Sci Total Environ. 2021 Apr 10;764:142880. doi: 10.1016/j.scitotenv.2020.142880.

3.Zhang W, Sun X, Qi X, Liu X, Zhang Y, Qiao S, Lin H. Di-(2-Ethylhexyl) Phthalate and Microplastics Induced Neuronal Apoptosis through the PI3K/AKT Pathway and Mitochondrial Dysfunction. J Agric Food Chem. 2022 Sep 7;70(35):10771-10781. doi: 10.1021/acs.jafc.2c05474.

4.Cui Y, Zhang Q, Yin K, Song N, Wang B, Lin H. DEHP-induce damage in grass carp hepatocytes and the remedy of Eucalyptol. Ecotoxicol Environ Saf. 2020 Dec 15;206:111151. doi: 10.1016/j.ecoenv.2020.111151.

5.Lei Y, Zhang W, Gao M, Lin H. Mechanism of evodiamine blocking Nrf2/MAPK pathway to inhibit apoptosis of grass carp hepatocytes induced by DEHP. Comp Biochem Physiol C Toxicol Pharmacol. 2023 Jan;263:109506. doi: 10.1016/j.cbpc.2022.109506.

6.Yin K, Sun X, Zheng Y, Zhang W, Lin H. Bisphenol A exacerbates selenium deficiency-induced pyroptosis via the NF-κB/NLRP3/Caspase-1 pathway in chicken trachea. Comp Biochem Physiol C Toxicol Pharmacol. 2023 Jan;263:109488. doi: 10.1016/j.cbpc.2022.109488.

7.Lei Y, Xu T, Sun W, Wang X, Gao M, Lin H. Evodiamine alleviates DEHP-induced hepatocyte pyroptosis, necroptosis and immunosuppression in grass carp through ROS-regulated TLR4 / MyD88 / NF-κB pathway. Fish Shellfish Immunol. 2023 Sep;140:108995. doi: 10.1016/j.fsi.2023.108995.

8.Sun J, Wang X, Xu T, Ren M, Gao M, Lin H. Quercetin antagonizes apoptosis, autophagy and immune dysfunction induced by di(2-ethylhexyl) phthalate via ROS/ASK1/JNK pathway. Comp Biochem Physiol C Toxicol Pharmacol. 2024 Nov;285:109991. doi: 10.1016/j.cbpc.2024.109991.

9.Xu T, Chen T, Shi X, Ding J, Chen S, Lin H. Co-exposure of bisphenol A and selenium deficiency induces pyroptosis via ROS/NLRP3 pathway in chicken spleen. Poult Sci. 2024 Oct;103(10):104150. doi: 10.1016/j.psj.2024.104150.

10.Cui Y, Yin K, Gong Y, Qu Y, Liu H, Lin H. Atrazine induces necroptosis by miR-181-5p targeting inflammation and glycometabolism in carp lymphocytes. Fish Shellfish Immunol. 2019 Nov;94:730-738. doi: 10.1016/j.fsi.2019.09.068.

11.Gao M, Zhu H, Guo J, Lei Y, Sun W, Lin H. Tannic acid through ROS/TNF-α/TNFR 1 antagonizes atrazine induced apoptosis, programmed necrosis and immune dysfunction of grass carp hepatocytes. Fish Shellfish Immunol. 2022 Oct 8;131:312-322. doi: 10.1016/j.fsi.2022.09.062.

12.Gao M, Yang N, Lei Y, Zhang W, Liu H, Lin H. Tannic acid antagonizes atrazine exposure-induced autophagy and DNA damage crosstalk in grass carp hepatocytes via NO/iNOS/NF-κB signaling pathway to maintain stable immune function. Fish Shellfish Immunol. 2022 Nov 14;131:1075-1084. doi: 10.1016/j.fsi.2022.11.024.

13.Wang X, Sun J, Xu T, Lei Y, Gao M, Lin H. Resveratrol alleviates imidacloprid-induced mitochondrial apoptosis, necroptosis, and immune dysfunction in chicken lymphocyte lines by inhibiting the ROS/MAPK signaling pathway. Environ Toxicol. 2024 Apr;39(4):2052-2063. doi: 10.1002/tox.24097.

14.Cui Y, Qu Y, Yin K, Zhang X, Lin H. Selenomethionine ameliorates LPS-induced intestinal immune dysfunction in chicken jejunum. Metallomics. 2021 Mar 8;13(3):mfab003. doi: 10.1093/mtomcs/mfab003.

15.Li J, Zhang W, Zhou P, Tong X, Guo D, Lin H. Selenium deficiency induced apoptosis via mitochondrial pathway caused by Oxidative Stress in porcine gastric tissues. Res Vet Sci. 2022 May;144:142-148. doi: 10.1016/j.rvsc.2021.10.017.

16.Li L, Li W, Liu Y, Han B, Yu Y, Lin H. Emamectin benzoate exposure induced carp kidney injury by triggering mitochondrial oxidative stress to accelerate ferroptosis and autophagy. Pestic Biochem Physiol. 2024 Aug;203:106017. doi: 10.1016/j.pestbp.2024.106017.

17.Ren M, Lv X, Xu T, Sun J, Gao M, Lin H. Effects of atrazine and curcumin exposure on TCMK-1 cells: Oxidative damage, pyroptosis and cell cycle arrest. Food Chem Toxicol. 2024 Mar;185:114483. doi: 10.1016/j.fct.2024.114483.

18.Wang X, Sun J, Xu T, Lei Y, Gao M, Lin H. Resveratrol alleviates imidacloprid-induced mitochondrial apoptosis, necroptosis, and immune dysfunction in chicken lymphocyte lines by inhibiting the ROS/MAPK signaling pathway. Environ Toxicol. 2024 Apr;39(4):2052-2063. doi: 10.1002/tox.24097.

19.Zhang W, Yin K, Shi J, Shi X, Qi X, Lin H. The decrease of selenoprotein K induced by selenium deficiency in diet improves apoptosis and cell progression block in chicken liver via the PTEN/PI3K/AKT pathway. Free Radic Biol Med. 2022 Aug 20;189:20-31. doi: 10.1016/j.freeradbiomed.2022.07.005.

20.Zhang Y , Qi X , Chen X , Zhang J , Zhang W , Lin H . Dietary selenomethionine ameliorates lipopolysaccharide-induced renal inflammatory injury in broilers via regulating the PI3K/AKT pathway to inhibit necroptosis. Food Funct. 2021 May 21;12(10):4392-4401. doi: 10.1039/d1fo00424g.

21.Li X, Chen M, Yang Z, Wang W, Lin H, Xu S. Selenoprotein S silencing triggers mouse hepatoma cells apoptosis and necrosis involving in intracellular calcium imbalance and ROS-mPTP-ATP. Biochim Biophys Acta Gen Subj. 2018 Oct;1862(10):2113-2123. doi: 10.1016/j.bbagen.2018.07.005.

22.Yin K, Cui Y, Sun T, Qi X, Zhang Y, Lin H. Antagonistic effect of selenium on lead-induced neutrophil apoptosis in chickens via miR-16-5p targeting of PiK3R1 and IGF1R. Chemosphere. 2020 May;246:125794. doi: 10.1016/j.chemosphere.2019.125794.

23.Yin K, Yang Z, Gong Y, Wang D, Lin H. The antagonistic effect of Se on the Pb-weakening formation of neutrophil extracellular traps in chicken neutrophils. Ecotoxicol Environ Saf. 2019 May 30;173:225-234. doi: 10.1016/j.ecoenv.2019.02.033.

24.Qi X, Zhang Y, Liu H, JinxiZhang, WeiWang, Lin H. Cadmium exposure induces inflammation and necroptosis in porcine adrenal gland via activating NF-κB/MAPK pathway. J Inorg Biochem. 2021 Oct;223:111516. doi: 10.1016/j.jinorgbio.2021.111516.

25.Qi X, Ren Z, Cui Y, Zhang J, Zhang Y, Wang S, Lin H. Cadmium induces apoptosis by miR-9-5p targeting PTEN and regulates the PI3K/AKT pathway in the piglet adrenal gland. Environ Sci Pollut Res Int. 2022 Oct;29(48):73001-73010. doi: 10.1007/s11356-022-20734-9.

26.Yin K, Cui Y, Qu Y, Zhang J, Zhang H, Lin H. Hydrogen sulfide upregulates miR-16-5p targeting PiK3R1 and RAF1 to inhibit neutrophil extracellular trap formation in chickens. Ecotoxicol Environ Saf. 2020 May;194:110412. doi:10.1016/j.ecoenv.2020.110412.

27.Wang W, Chen M, Jin X, Li X, Yang Z, Lin H, Xu S. H2S induces Th1/Th2 imbalance with triggered NF-κB pathway to exacerbate LPS-induce chicken pneumonia response. Chemosphere. 2018 Oct;208:241-246. doi: 10.1016/j.chemosphere.2018.05.152.

28.Li L, Li W, Liu Y, Jin X, Yu Y, Lin H. TBBPA and lead co-exposure induces grass carp liver cells apoptosis via ROS/JAK2/STAT3 signaling axis. Fish Shellfish Immunol. 2023 Nov;142:109100. doi: 10.1016/j.fsi.2023.109100.

29.Zhang W, Sun X, Shi X, Qi X, Shang S, Lin H. Subacute Cadmium Exposure Induces Necroptosis in Swine Lung via Influencing Th1/Th2 Balance. Biol Trace Elem Res. 2023 Jan;201(1):220-228. doi: 10.1007/s12011-022-03133-6.

30.Zhang Y, Li Y, Zhang J, Qi X, Cui Y, Yin K, Lin H. Cadmium induced inflammation and apoptosis of porcine epididymis via activating RAF1/MEK/ERK and NF-κB pathways. Toxicol Appl Pharmacol. 2021 Mar 15;415:115449. doi: 10.1016/j.taap.2021.115449.

31.Zhang J, Zhang Y, Qi X, Cui Y, Chen X, Lin H. TRAF2/ASK1/JNK Signaling Pathway Is Involved in the Lung Apoptosis of Swine Induced by Cadmium Exposure. Biol Trace Elem Res. 2022 Jun;200(6):2758-2766. doi: 10.1007/s12011-021-02860-6.

32.Liu L, Yang B, Cheng Y, Lin H. Ameliorative Effects of Selenium on Cadmium-Induced Oxidative Stress and Endoplasmic Reticulum Stress in the Chicken Kidney. Biol Trace Elem Res. 2015 Oct;167(2):308-19. doi: 10.1007/s12011-015-0314-7.

33.Bao R, Wang X, Zheng S, Zhang Q, Lin H, Li S. Selenium Supplementation Changes the Ion Profile in the Pancreas of Chickens Treated with Cadmium. Biol Trace Elem Res. 2018 Jan;181(1):133-141. doi: 10.1007/s12011-017-1034-y.

34.Liu R, Jia T, Cui Y, Lin H, Li S. The Protective Effect of Selenium on the ChickenPancreas against Cadmium Toxicity via Alleviating Oxidative Stress and Autophagy. Biol Trace Elem Res. 2018 Jul;184(1):240-246. doi: 10.1007/s12011-017-1186-9.

35.Lv X, Ren M, Xu T, Gao M, Liu H, Lin H. Selenium alleviates lead-induced CIK cells pyroptosis and inflammation through IRAK1/TAK1/IKK pathway. Fish Shellfish Immunol. 2023 Nov;142:109101. doi: 10.1016/j.fsi.2023.109101.

36.Zheng SF, Bao RK, Zhang QJ, Wang SC, Lin HJ. Endogenous Hydrogen Sulfide Promotes Apoptosis via Mitochondrial Pathways in the Livers of Broilers with Selenium Deficiency Exudative Diathesis Disease. Biol Trace Elem Res. 2018 Nov;186(1):249-257. doi: 10.1007/s12011-018-1292-3.

37.Jing H, Gao X, Xu L, Lin H, Zhang Z. H2S promotes a glycometabolism disorder by disturbing the Th1/Th2 balance during LPS-induced inflammation in the skeletal muscles of chickens. Chemosphere. 2019 May;222:124-131. doi: 10.1016/j.chemosphere.2019.01.136.

38.Liu XF, Zhang LM, Zhang Z, Liu N, Xu SW, Lin HJ. Manganese-induced effects on testicular trace element levels and crucial hormonal parameters of Hyline cocks. Biol Trace Elem Res. 2013 Feb;151(2):217-24. doi: 10.1007/s12011-012-9549-8.

著作:

1.主编,农业部“十一五”规划教材《动物营养与饲料》,中国农业科技出版社2008.08。

2.主编,黑龙江省“村村大学生计划”专业教材《动物营养与饲料》,黑龙江人民出版社,2005.08。

3.编著,黑土地农村书屋《奶牛“四大系列”疾病防治》,黑龙江科学技术出版社,2004.02。

1.DB23/T 725-2016有机食品肉鸡养殖技术操作规程黑龙江省地方标准 2016-11-03第2名

2.DB23/T 1107-2016有机食品肉鹅养殖技术操作规程黑龙江省地方标准 2016-11-03第2名