兽医产科学教研室

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姓名: 赵立佳

职称: 副教授

系别: 临床兽医学

研究领域: 动物生殖内分泌,兽医产科学基础,生殖毒理,哺乳动物生殖生物钟

办公电话:

电子邮箱: ljzhao@neau.edu.cn

个人简介
人才称号
社会兼职
科研项目
讲授课程
论文著作

赵立佳,男,吉林长春人,中共党员,东北农业大学动物医学院副教授、硕士生导师,东北农业大学东农学者计划“学术骨干”,日本九州大学动物繁殖生理学博士(国家公派),西北农林科技大学兽医学博士后,中国畜牧兽医学会高级会员,中国细胞生物学学会会员,国家留学基金委公派项目评审专家。主持国家自然科学基金青年科学基金项目、中国博士后科学基金第65批面上项目一等资助、黑龙江省优秀青年基金。2021年12月入职东北农业大学动物医学院,主要从事兽医产科学基础、哺乳动物生物钟调控生殖等相关研究。


黑龙江省E类人才


中国畜牧兽医学会兽医产科学分会高级会员

中国细胞生物学会会员

国家留学基金委公派留学项目评审专家

全国本科毕业论文(设计)抽检评审专家

黑龙江猪蓝耳病双阴百场工程项目专家


1.黑龙江省自然科学基金,优秀青年基金项目,YQ2022C018,生物钟基因Bmal1通过调控Apoa1影响睾酮合成的机制研究,2022-07至2025-07,在研,主持。

2.东北农业大学,东农学者计划“学术骨干”项目,生物钟基因Nr1d1调控牛子宫内膜细胞自噬的分子机制研究,2021-12至2024-12,在研,主持。

3.国家自然科学基金委员会,青年科学基金项目,31900838,生物钟核受体NR1D1调控子宫内膜基质细胞蜕膜化过程的作用机制,2020-01至2022-12,25万元,已结题,主持。

4.中国博士后科学基金委员会,第65批博士后面上资助一等资助,2019M650279,生物钟基因Bmal1调控睾丸间质细胞睾酮合成的机制研究,2019-05至2021-04,12万元,已结题,主持。

兽医产科学(本科生);兽医产科学实验(本科生);普通病综合诊治大实验(本科生);生殖内分泌学(硕士生);学术论文写作与学术规范(硕士),家畜胚胎移植(硕士);兽医临床实践与案例分析(博士生)


论文:

1.Feilong Pan, Wenzhe Yang, Tong Zhao, Kexiang Liu, Shuchen Zhao, Lijia Zhao, Procyanidine alleviates bisphenol A-induced apoptosis inTM3 cells viathe Nrf2 signaling pathway.Food and Chemical Toxicology, 2024.

2. 赵树臣,王海涛,刘克祥,侯振中,赵立佳*,棉酚对小鼠睾丸氧化损伤及NF-κB、P53和Caspase-3基因表达的影响,东北农业大学学报,2024

3.赵彤,杨文哲,潘飞龙,赵树臣,刘克祥,吕占军,赵立佳*,双酚A通过上调Apoa1基因的表达抑制TM3细胞睾酮合成,畜牧兽医学报,2024

4.赵立佳,刘克祥,赵树臣,提升《兽医产科学》教学效果的方法探索与实践,畜禽业,2024

5.杨文哲,刘克祥,王诗睿,赵彤,潘飞龙,赵树臣,赵立佳*,基于线粒体损伤探讨BPA诱导TM3细胞凋亡的研究,中国畜牧兽医,2024

6.杨文哲,赵彤,潘飞龙,王锦浩,陈芳芳,邵雯琪,王诗睿,赵树臣,刘克祥,赵立佳*,辅酶Q10通过自噬调控双酚A诱导的TM3细胞凋亡,中国兽医学报,2024

7.刘克祥,赵树臣,赵立佳*,科研成果与临床案例在《兽医产科学》教学中的应用探索,畜牧兽医杂志,2024

8. 赵树臣,赵立佳,刘克祥,曹峥,《兽医产科学》思政元素的应用与创新,当代畜牧,2023

9.Gao Dengke#, Ma Tiantian#, Gao Lei#, Zhang Jing, Zhang Haisen, Zhang Linlin, Dong Hao, Li Yating, Zhao Lijia, Liu Wei, Zhao Hongcong, Li Dan, Zhou Dong, Wang Aihua, Jin Yaping, Chen Huatao*, Autophagy activation attenuates the circadian clock oscillators in U2OS cells via the ATG5 pathway.Cellular Signalling, 2023

10.Liguang Wang, Jingjing Li, Lutong Zhang, Shengjie Shi, Xiaoge Zhou, Yamei Hu, Lei Gao, Gongshe Yang, Weijun Pang, Huatao Chen, Lijia Zhao, Guiyan Chu, Chuanjiang Cai,NR1D1 targeting CYP19A1 inhibits estrogen synthesis in ovarian granulosa cells.Theriogenology, 2022

11.Zhao Lijia#, Zhang Jing#, Yang Luda, Zhang Haisen, Zhang Yu, Gao Dengke, Jiang Haizhen, Li Yating, Dong Hao, Ma Tiantian, Wang Xiaoyu, Wu Meina, Wang Aihua, Jin Yaping, Yuan Yalin, Chen Huatao*,Glyphosate exposure attenuates testosterone synthesis via NR1D1 inhibition of StAR expression in mouse Leydig cells.Science of the Total Environment, 2021.

12.Zhao Lijia, Yang Luda, Zhang Jing, Xiao Yaoyao, Wu Meina, Ma Tiantian, Wang Xiaoyu, Zhang Linlin, Jiang Haizhen, Chao Hsu-wen, Wang Aihua, Jin Yaping*, Chen Huatao*,Bmal1promotes prostaglandin E2synthesis by up-regulatingPtgs2transcription in response to increasing estradiol levels in day 4 pregnant mice,American Journal of Physiology-Endocrinology and Metabolism, 2021.

13.Zhao Lijia#, Xiao Yaoyao#, Li Cuimei, Zhang Jing, Zhang Yaojia, Wu Meina, Ma Tiantian, Yang Luda, Wang Xiaoyu, Jiang Haizhen, Li Qian, Zhao Hongcong, Wang Yiqun, Wang Aihua, Jin Yaping*, Chen Huatao*, Zearalenone perturbs the circadian clock and inhibits testosterone synthesis in mouse Leydig cells,Journal of Toxicology and Environmental Health, Part A, 2020.

14.Zhang Jing#, Zhao Lijia#, Li Yating, Dong Hao, Zhang Haisen, Zhang Yu, Ma Tiantian, Yang Luda, Gao Dengke, Wang Xiaoyu, Jiang Haizhen, Li Chao, Wang Aihua, Jin Yaping, Chen Huatao*, Circadian clock regulates granulosa cell autophagy through NR1D1-mediated inhibition of ATG5.American Journal of Physiology-Cell Physiology, 2021.

15.Xiao Yaoyao#, Zhao Lijia#, Li Weidong, Wang Xiaoyu, Ma Tiantian, Yang Luda, Gao Lei, Li Cuimei, Zhang Manhui, Yang Dan, Zhang Jing, Jiang Haizhen, Zhao Hongcong, Wang Yiqun, Chao Hsu-wen, Wang Aihua, Jin Yaping*, Chen Huatao*, Circadian clock gene BMAL1 controls testosterone production by regulating steroidogenesis-related gene transcription in goat Leydig cells,Journal of Cellular Physiology, 2021.

16.Yang Luda, Ma Tiantian, Zhao Lijia, Jiang Haizhen, Liu Dongyao, Zhang Linlin, Wang Xiaoyu, Pan Tao, Zhang Haisen, Wang Aihua, Chao Hsu-wen, Jin Yapin*, Chen Huatao*, Circadian regulation of apolipoprotein genes expression affects testosterone production in mouse testis.Theriogenology.2021

17.Li Cuimei#, Zhang Linlin#, Ma Tiantian, Gao Lei, Yang Luda, Wu Meina, Pang Zhaoxia, Wang Xiaoyu, Yao Qiyang, Xiao Yaoyao, Zhao Lijia, et al. Bisphenol A attenuates testosterone production in Leydig cells via the inhibition of NR1D1 signaling. Chemosphere, 263, 128020, 2020.

18.Zhao Lijia, Isayama Keishiro, Chen Huatao, et al., The nuclear receptor REV-ERB alpha represses the transcription of growth/differentiation factor 10 and 15 genes in rat endometrium stromal cells,Physiological Reports, 2016, 4(2).

19.Tasaki Hirotaka#, Zhao Lijia#, Isayama Keishiro, et al. Inhibitory role of REB-ERBα in the expression of bone morphogenetic protein gene family in rat uterus endometrium stromal cells.American Journal of Physiology-Cell Physiology, 2015, 308: C528-C538.

20.Isayama Keishiro, Zhao Lijia, Chen Huatao, et al. Attenuation of uterus circadian clock during decidualization: Removal of REV-ERBα inhibition contributes toPtgs2expression in rat endometrial stromal cells.American Journal of Physiology-Endocrinology and Metabolism, 2015, 308: E650-E661.

21.Chen Huatao, Isayama Keishiro, Kumazawa Makoto, Zhao Lijia, et al. Integration of the nuclear receptor REV-ERBα linked to circadian oscillators in the expression ofAlas1,Ppargc1a, andIl6genes in rat granulosa cells.Chronobiology International, 2015. (IF:2.486)

22.Tasaki Hirotaka#, Zhao Lijia#, Isayama Keishiro, et al. Gene profiling of the circadian oscillations in the uterus endometrial stromal cells of pregnant rats by DNA microarray analysis coupled with RNA interference.Frontiers in Endocrinology4: 82, 2013.

23.Chen Huatao, Zhao Lijia, Chu Guiyan, et al. FSH induces the development of circadian clockwork in rat granulosa cells via a gap junction protein Cx43-dependent pathway.American Journal of Physiology-Endocrinology and Metabolism, 2013, 304: E566-E575.

24.Chen Hutao, Zhao Lijia, Kumazawa Makoto, et al. Down-regulation of core clock geneBmal1attenuates expression of progesterone and prostaglandin biosynthesis-related genes in rat luteinizing granulosa cells.American Journal of Physiology-Cell Physiology, 2013, 304: C1131-C1140.

25.Chen Huatao, Chu Guiyan, Zhao Lijia, et al. Rev-erbα regulates circadian rhythms andStARexpression in rat granulosa cells as identified by the agonist GSK4112.Biochemical and Biophysical Research Communications, 2012, 420: 374-379.

著作:

《兽医产科学》第二版,科学出版社,参编

《猫繁育》,湖北科学技术出版社,参译