东北农业大学副教授，硕士生导师，黑龙江优秀青年科学基金获得者，黑龙江省高层次人才（E类），东北农业大学“学术骨干”，入选黑龙江省普通高等学校青年人才培养计划，黑龙江省博士后青年英才计划等。主要围绕药物畜禽感染性疾病治疗的核心问题展开科学研究，通过构建新型兽用制剂，提高抗菌药物疗效。主持国家自然科学基金青年项目，中国博士后基金特别资助项目等项目多项；以第一或通讯作者在Advanced Materials等中科院1区TOP期刊上发表论文发表论文8篇，单篇最高影响因子29.7，影响因子大于10的4篇；授权发明专利4项。
（1）高载药量的生物响应型异甘草二聚体纳米粒清除MRSA生物被膜的研究，国家自然基金青年项目，2022.01-2025.12，30万
（2）基于植物化学的纳米颗粒特异性结合并有效消除胞内MRSA的研究，中国博士后基金特别资助项目，2022.07-2025.07，18万
（3）靶向纳米中药控释体系的构建及其用于胞内MRSA感染治疗的研究，黑龙江省自然科学基金优秀青年基金项目，2022.07-2025.07，10万
（4）细菌靶向雷公藤红素脂质体用于耐甲氧西林金黄色葡萄球菌感染治疗的研究/黑龙省博士后基金特别资助目，2022.01-2024.12，20万
（5）多功能纳米制剂的构建及抗MRSA生物被膜感染的研究，黑龙江省普通本科高等学校青年创新人才培养计划，2021.01-2023.12，10万
（6）α-生育酚-壳聚糖纳米制剂增强中药抗耐甲氧西林金黄色葡萄球菌效果的研究，中国博士后基金面上项目，2020-2023，8万
（7）中药纳米制剂的制备及抗MRSA生物被膜感染的研究，黑龙江省博士后基金面上项目，2020-2023，7万
(1)Shuang Cai, Linlin Wang, Xilong Cui,Xinshu Zou, Sidi Zheng,Fanhui Liu, Chun Shi, Yanhua Li*, Zhiyun Zhang*,Rhein-loaded chitosan nanoparticles for treatment of MRSA-infected wound,International Journal of Biological Macromolecules, 2024, 27:135360 (IF =10.7)
(2)Wang Tingting,Cui Xilong,Cai Shuang,Zou Xinshu,Zheng Sidi,Li Yanhua*,ZhangZhiyun*,Multifunctional phytochemical nanoplatform for comprehensive treatment of all-stage MRSA biofilm associated infection and its accompanying inflammation, Chemical Engineering Journal, 2024, 480: 147951.(中科院1区TOP，IF=15.1)
(3)Xilong Cui, Fanhui Liu, Shuang Cai, Tingting Wang, Sidi Zheng, Xinshu Zou, Linlin Wang, Siqi He, Yanhua Li*,Zhiyun Zhang*,Charge Adaptive Phytochemical-based Nanoparticles for Eradication of Methicillin-Resistant Staphylococcus aureus Biofilms, Asian Journal of Pharmaceutical Sciences, 2024,19(3):100923 (中科院1区，IF=10.7)
(4)Zou Xinshu,Cai Shuang,Wang Tingting,Zheng Sidi,Cui Xilong,Hao Jingyou,Chen Xueying,Liu Yanyan,Zhang Zhiyun*,Li Yanhua*,Natural antibacterial agent-based nanoparticles for effective treatment of intracellular MRSA infection, Acta Biomaterialia, 2023, 169: 410-421.(中科院1区TOP，IF=9.7)
(5)XingChen, Wen-Qiang Cui, Yue Zhang, Xin-Shu Zou, Jing-YouHao, Si-DiZheng,Ting-Ting Wang, Xiao-Zhen Wang, TongWu,Yan-YanLiu,Xue-Ying Chen, Shu-Guang Yuan,Zhi-Yun Zhang*, Yan-Hua Li*,Ultrasound-assisted deep eutectic solvents extraction of glabridin and isoliquiritigenin from Glycyrrhiza glabra: Optimization, extraction mechanism and in vitro bioactivities,Ultrasonics Sonochemistry,2022,83:105946.（中科院1区TOP，IF =8.8)
(6)Zhiyun Zhang, Gaizhen Kuang, Shan Zong, Shi Liu, Haihua Xiao, Xuesi Chen, Dongfang Zhou,* and Yubin Huang*,Sandwich-Like Fibers/Sponge Composite Combining Chemotherapy and Hemostasis for Efficient Postoperative Prevention of Tumor Recurrence and Metastasis, Advanced Materials,2018, 1803217(中科院1区TOP，IF=27.4)
(7)Zhiyun Zhang, Shi Liu, Yanxin Qi, Dongfang Zhou⁎, Zhigang Xie, Xiabin Jing, Xuesi Chen, Yubin Huang⁎,Time-programmed DCA and oxaliplatin release by multilayered nanofiber mats in prevention of local cancer recurrence following surgery, Journal of Controlled Release, 2016, 235, 125-133（中科院1区TOP，IF=10.7）
(8)ZhangZhiyun, LiuShia,XiongHejian, JingXiabin, XieZhigang, ChenXuesi, HuangYubin,Electrospun PLA/MWCNTs composite nanofibers for combined chemo- and photothermal therapy, Acta Biomaterialia, 2015, 26, 115-123（中科院1区TOP，IF=9.4）
